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Scott Asbill, Samford University, Birmingham, Alabama, Transdermal Drug Delivery Maria Fernanda Bahia, University of Porto, Porto, Portugal, Vaginal Drug Delivery Bernard Bataille, University of Montpelier 1, Montpellier, France, Tablet Design Gerald W. It is a 9 - h adhesive matrix patch and comes in four sizes: a 12.5 - cm 2 patch that has a delivery rate of 1.1 mg/h, an 18.75 - cm 2 patch that has a delivery rate of 1.6 mg/h, a 25 - cm 2 patch that delivers 2.2 mg/h, and a 37.5 - cm 2 patch that delivers 3.3 mg/h. As the epithelium is hormonally dependent, its permeability also changes, usually decreasing with higher estrogen levels because of the induced membrane thickening. 22.214.171.124 Top - Down and Bottom - Up Approaches to Nanotechnology There are generally two approaches to nanotechnology, the top - down and bottom - up approaches.
Becker, SSCI, West Lafayette, Indiana, Biotechnology - Derived Drug Product Development; Regulatory Considerations in Approval of Follow - On Protein Drug Products B. 5.11.8 CHEMICAL AND PHYSICAL APPROACHES TO TRANSERMAL DELIVERY Due to the brick - and - mortar structure of the stratum corneum, the skin is a diffi cult layer to permeate across for most active pharmaceutical ingredients. ( 2006 ), Dynamics of skin barrier repair following topical applications of miconazole nitrate , Skin Pharmacol. However, contradictory fi ndings of enhanced vaginal absorption in postmenopausal women treated with estrogen have been reported  . As the names suggest, the top - down approach utilizes ultraprecision machining and nanolithographic techniques among others to achieve very high defi nition structures with nanolevel accuracy, usually either by removing material from the surface of a larger structure until the desired structure with desired features is achieved or through deposition of material with almost atomic - scale precision and control.